05/12/2025
PORTAL HYPERTENSION
By Chipo James Mainda
The liver is the largest gland in the body. It weighs between 1-2.3kg. It is situated largely in the upper right hypochondriac region, part of the epigastric and left hypochondriac region. Functions of the liver include;
* Carbohydrate, fat, and protein metabolism.
* Breakdown of old red blood cells.
* Defence against microbes.
* Detoxification of drugs and noxious substances such as alcohol.
* Production of heat.
* Production of bile, etc.
Portal hypertension is a chronic condition of the accessory organ of the digestive system, the liver, in which there is sustained elevation or an increase in the blood pressure within a system of veins called the portal venous system (which are veins coming from the stomach, intestine, spleen, and pancreas merge into the portal vein, which then branches into smaller vessels and travels through the liver) for more than 12mmHg, usually due to liver cirrhosis, characterized by esophageal varices and splenomegaly.
If the blood vessels in the liver are blocked due to liver damage, blood can not flow properly through the liver. As a result, high blood pressure in the portal system develops. This increased pressure in the portal vein may lead to backflow of blood resulting in development of large, swollen veins (varices) within the esophagus, stomach, re**um, or umbilical area. Varices can rupture in severe cases and bleed, resulting in potentially life threatening complications. The normal blood pressure in the portal venous circulation is 8-12mmHg.
Increased resistance of portal flow of blood may develop in different circumstances, these causes can be divided into;
* Prehepatic causes, which follows an obstruction or narrowing of the portal vein before entering the liver.
* Intrahepatic causes, which is damage to the liver itself. This account for most cases of portal hypertension.
* Post hepatic causes, which is obstruction occurs at any level between the liver and right side of the heart
The signs and symptoms include the following: ascites, splenomegaly, esophageal varices, caput medusae, hematemesis, melena, oedema of the lower limbs. Medical therapy of bleeding esophageal or gastric varices may be instituted once the cause of hemorrhage is documented to be variceal in origin. Drug treatment is aimed at reducing portal blood flow such as use of nonselective beta blockers, vasopressin etc
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