Carmine Belin Lab

Carmine Belin Lab Research laboratory at the Karolinska Institutet, Stockholm, focusing on neurological disorders like primary headache disorders.

The purpose of our research is to increase the understanding of the pathophysiology of neurological disorders with a focus on primary headache disorders such as migraine and cluster headache (CH) by identifying, characterizing and modelling genetic markers within the human genome. Certain rare forms of these conditions are monogenic and there is increasing evidence that genetic factors are importa

nt also for sporadic forms. We suggest that there are multiple genetic factors that combine in different ways to increase or decrease risk for disease. They need to be identified in order to begin unwinding the causative pathways leading to the different forms of the disorders. Knowledge about gene function and findings from linkage and genome-wide association studies are applied to clinical material (DNA and cell lines) collected from patients with migraine and CH as well as neurologically healthy controls to decipher genetic factors. Key genetic findings are evaluated by:

1. Quantification of possible candidate gene and protein expression differences caused by genetic variation in biological samples and in silico

2. Characterization of candidate gene and protein expression in human and rodent tissue

3. Development and characterization of transgenic animal models. The identification of new genetic risk and protective markers for these disorders should allow insight into the pathophysiological mechanisms, and thereby lead to improved diagnosis and aid in the development of novel classes of drugs able to prevent and/or counteract disease.

Excited to see our work on molecular clock dysfunction and cluster headache at the Centre for Cluster Headache published...
14/04/2026

Excited to see our work on molecular clock dysfunction and cluster headache at the Centre for Cluster Headache published in Cephalalgia! Thank you all co-authors for a great collaboration!

Background / Hypothesis Headache attacks are reported to occur with circadian rhythmicity by 2/3 of individuals with cluster headache, hinting to potential dysf...

Congratulations Felicia and Jacob🥳!
02/04/2026

Congratulations Felicia and Jacob🥳!

21/03/2026

Today is Cluster Headache Awareness Day!!!

Yesterday PhD student Clémence Deborgies gave an appreciated talk on our cluster headache research projects as part of ...
20/03/2026

Yesterday PhD student Clémence Deborgies gave an appreciated talk on our cluster headache research projects as part of the 🤩!

Today we congratulate PhD student Clémence Deborgies on having her first manuscript accepted for publication in Cephalal...
10/03/2026

Today we congratulate PhD student Clémence Deborgies on having her first manuscript accepted for publication in Cephalalgia💐!

Happy to share that our work at Centre for Cluster Headache has been awareded new funding from Region Stockholm! Gratefu...
03/03/2026

Happy to share that our work at Centre for Cluster Headache has been awareded new funding from Region Stockholm! Grateful for all collaborators and especially co-applicants Caroline Ran at Karolinska Institutet, Anna Steinberg and Anna Sundholm at Karolinska Universitetssjukhuset and Christina Sjöstrand at Danderyds Sjukhus.

New funding from Region Stockholm will support advanced research into cluster headache at Karolinska Institutet. By combining genetic studies with sleep and circadian rhythm research, the project seeks to improve care for a patient group with a high disease burden and risk of misdiagnosis.

Caroline Ran and Andrea Carmine Belin from Centre for Cluster Headache had great fun attending the 2026 Research Project...
17/02/2026

Caroline Ran and Andrea Carmine Belin from Centre for Cluster Headache had great fun attending the 2026 Research Project Fair to recruit the next generation of promising scientists🤩!

23/01/2026

🔴 Cluster Headache: Genetics, Diagnosis & New Therapies

What drives cluster headache — and what’s next for treatment?
Andrea Carmine Belin (Karolinska Institutet, Sweden) discusses the genetics of cluster headache, key diagnostic features, and promising new therapies on the horizon.

🎙️ Interviewed by Amr Hassan
🎥 Watch here:
https://www.youtube.com/watch?v=_4WJdtifQKc

YOURHEAD: Ny forskningsstudie på Karolinska Insitutet söker deltagare diagnostiserad primär huvudvärk (högfrekvent migrä...
15/01/2026

YOURHEAD: Ny forskningsstudie på Karolinska Insitutet söker deltagare diagnostiserad primär huvudvärk (högfrekvent migrän och/eller klusterhuvudvärk) för yogabaserade kroppsövningar:

Har du diagnostiserad primär huvudvärk som högfrekvent migrän och/eller klusterhuvudvärk? Forskare söker dig som vill testa om yogabaserade kroppsövningar kan hjälpa dig att förbättra din hälsa genom vägledd webbaserad digifysisk träning under 8–12 veckor.

We wish all our followers Happy Holidays🎅🏻🎄🎁!
23/12/2025

We wish all our followers Happy Holidays🎅🏻🎄🎁!

Best lab gifts ever 🧠 ! Crocheted brain key chains by bachelor student Julia Swedblom on her last day🤩! Good luck with y...
19/12/2025

Best lab gifts ever 🧠 ! Crocheted brain key chains by bachelor student Julia Swedblom on her last day🤩! Good luck with your future studies Julia and welcome back💕!

Beautiful conferment ceremony at the Stockholm City Hall for all the new doctors at Karolinska Institutet🎩! Congratulati...
15/11/2025

Beautiful conferment ceremony at the Stockholm City Hall for all the new doctors at Karolinska Institutet🎩! Congratulations to Felicia in out team🤩!

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Solnavägen 9
Stockholm
17177

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+46852487051

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