Endocrine Associate of West Village, PC

Endocrine Associate of West Village, PC Endocrinology clinic, led by Dr. Anastasios Manessis in NYC. 36-36 33th Street
Suite 311
Long Island City, NY 11106
(1)

We also partner with our holistic wellness division, neXendo wellness, to highlight fully personalized care for chronic disease management and weight loss through lifestyle interventions.

Fasting influences the body's primary metabolic hormones:- Insulin decreases- Glucagon increasesThese hormonal changes *...
03/17/2026

Fasting influences the body's primary metabolic hormones:
- Insulin decreases
- Glucagon increases
These hormonal changes *can* help release stored fat, increase fatty acid oxidation, and improve metabolic flexibility.

But what are the differences (and risks) between men and women?

Men often show stronger improvements in metabolic markers during fasting, including reductions in blood glucose levels, and improved insulin sensitivity. Male s*x hormones may also help enhance the body's ability to regulate glucose metabolism.

Women's metabolic responses are often influenced by hormonal cycles, which can come with some fasting risks to be aware of.

Progesterone may increase glucose production, insulin sensitivity may fluctuate across the menstrual cycle, and estrogen also plays protective roles in blood vessel function and metabolic regulation.

Metabolism interacts with many biological systems like the immune system, vascular health, and hunger/regulation centers in the brain. Over time, disruptions in these systems can contribute to metabolic diseases such as type 2 diabetes.

Men may adapt to fasting more quickly due to differences in muscle mass and metabolic flexibility. Benefits may include:...
03/16/2026

Men may adapt to fasting more quickly due to differences in muscle mass and metabolic flexibility. Benefits may include:
- Improved metabolic efficiency
- Sustained energy levels during activity
- Improved cognitive focus during fasting periods

Women’s energy responses can vary more due to hormonal fluctuations throughout the menstrual cycle. During certain phases:
- Glycogen stores may be used more rapidly
- Fatigue may occur earlier during fasting or exercise.
- Hormonal changes can also influence mood, energy levels, and overall metabolic regulation.

Like all nutrition strategies, it isn’t one size fits all! But consider the risks and speak to a provider before trying something like this.

Day 2 of discussing intermittent fasting for women. What are the risks you should be aware of? Today let’s chat about th...
03/13/2026

Day 2 of discussing intermittent fasting for women. What are the risks you should be aware of?

Today let’s chat about the differences in body composition: between men and women, and what happens during fasting.

During fasting, the body gradually shifts from using glucose as its main fuel source to using fat.
This metabolic transition promotes:
- fat breakdown
- ketone production
- cellular recycling processes (autophagy) that support cellular health.

These metabolic changes can contribute to improvements in body composition and metabolic efficiency.

Differences between men and women?

Men often experience faster abdominal fat loss and better preservation of muscle mass due to testosterone - these changes can improve liver metabolism and insulin sensitivity.

But! Women typically store more subcutaneous fat around the HIPS and THIGHS, which is influenced by estrogen and tends to be more resistant to breakdown.

For women the result of this is slower fat loss and a higher likelihood of losing muscle mass than men during a prolonged fasting state.

Intermittent fasting… might be fine for men, but may be terrible for women? Let’s talk about it. For Men: Fasting may te...
03/12/2026

Intermittent fasting… might be fine for men, but may be terrible for women? Let’s talk about it.

For Men: Fasting may temporarily increase testosterone and growth hormones that support
- Muscle Maintenance and Growth
- Fat Burning
- Metabolic Efficiency

These hormonal changes may also help improve insulin sensitivity and reduce inflammation, contributing to better metabolic health.

….. but it’s different for women.

For Women: Hormonal responses are often more sensitive to energy availability. Because hormones fluctuate throughout the menstrual cycle

- Metabolism may be slightly higher in the follicular phase
- Insulin sensitivity can decrease during the luteal phase

Fasting may reduce signals that regulate reproductive hormones. In some cases, this can increase the risk of menstrual irregularities or hypothalamic amenorrhea. These lower reproductive hormone levels can also influence bone health and reproductive function.

Intermittent fasting, just like all nutrition and health strategies, should NEVER be ‘one size fits all. Check back tomorrow as we further explore the risks of intermittent fasting for women, discussing issue #2: body composition.

Research shows that only a certain type of exercise improves bone health; That’s why we’re proud to be partnering with o...
03/05/2026

Research shows that only a certain type of exercise improves bone health; That’s why we’re proud to be partnering with our neXendo division to offer the Onero™ program to our patients with osteoporosis!

We believe in this program, and that’s we’re offering free bone health evaluations until April 1st.

— Participants in the Onero™ program have seen improvements in bone density scans, lean muscle mass, balance, and a reported drop in falls and fractures after program completion.

Did you know that high blood sugar levels over time can cause damage to your heart, and increase your risk of heart dise...
02/26/2026

Did you know that high blood sugar levels over time can cause damage to your heart, and increase your risk of heart disease?

This month, take some time to focus on nutrition and making heart healthy diet swaps to protect your heart!

02/26/2026

We created our medical fitness program at neXendo to bridge the gap between healthcare and physical activity.

Our program is designed for individuals managing chronic conditions, recovering from injuries, or simply seeking safe and effective exercise plans.

Our certified fitness experts collaborate with healthcare providers to develop personalized workout routines that prioritize safety, strength, and long-term wellness.

Managing a chronic disease? Your body might need a specific
*type* of exercise that you're not practicing!
(This is especially true for PCOS and Osteoporosis)

02/26/2026

Vitamin D Deficiencies are running rampant in NYC right now!

Are you feeling extra exhausted for no reason? It's might be this.

NYC already gets less natural sunlight because of its distance from the equator- but during winter it's even less. Not just because of the weather, but because we are more bundled up when we are outside, and we are simply just going outdoors less!

A Vitamin D deficiency can cause more of these 'winter blues' symptoms than you might think. It could even be leading to an increase in chronic pain.

"This program didn't just help me work out, it helped me change my life." This is Abigail's neXendo Story. She's been pa...
02/18/2026

"This program didn't just help me work out, it helped me change my life." This is Abigail's neXendo Story. She's been part of our program since 2023, and has found incredible results in her overall health.

Nutrition, EXercise, ENDOcrinology. NYC wellness.

Winter is hard on circulation, so those living with diabetes need to pay extra attention to their feet during these cold...
02/16/2026

Winter is hard on circulation, so those living with diabetes need to pay extra attention to their feet during these colder days.

Early attention and prevention keeps you safe.

February is and it’s time to talk about the connections between heart between heart and foot health. Paying attention ...
02/15/2026

February is and it’s time to talk about the connections between heart between heart and foot health.

Paying attention to your feet can help protect your overall health!

In recognition of American Heart Month, we’re highlighting the role of lifestyle medicine in improving and maintaining c...
02/04/2026

In recognition of American Heart Month, we’re highlighting the role of lifestyle medicine in improving and maintaining cardiovascular health!

While cardiovascular disease is the #1 cause of death for women, the good news is that most can be prevented through education and lifestyle changes.

Heart health interventions should include nutrition, movement, sleep, weight management, blood pressure, and blood sugar regulation.

At neXendo Wellness, we focus on combining these in prevention-forward, individualized care plans that helps patients understand their health risks and take actionable steps toward long-term health.

Address

235 East 38th Street, Ground Floor
New York, NY
10016

Opening Hours

Monday 9am - 5:30pm
Tuesday 9am - 5pm
Wednesday 9am - 5pm
Thursday 9am - 5pm
Friday 9am - 5pm
Saturday 9am - 3pm

Telephone

+12126759332

Website

http://Nexendowellness.com/

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The Diabetes Center

Endocrine Associates of West Village is a medical practice in Manhattan and Long Island City that specializes in the treatment of patients with a wide range of endocrine-related disorders. Our team works with our patients every step of the way.

Our services include the following: Management of Gestational Diabetes, Diabetic Foot Care, Diabetic Eye Care, Certified Diabetes Nutritionists and Educators, Insulin Pump Specialists, Medical Fitness and Nutrition Program.

Dr. Manessis and his comprehensive team of weight loss and wellness experts are providing nutrition, fitness, and lifestyle modification in one program.

The curriculum in all of our programs are designed to teach the skills for both successful weight loss and maintenance. Visits are taught by Registered Dietitians with expertise in nutrition, exercise and lifestyle behavioral change.