10/15/2025
Glutathione (GSH) and NAD⁺ are both critical for cellular health, energy, and repair. Yet, they function very differently in the body. The question I'm often asked is, "Which one do I need?"
Let’s look at what they do:
⚡️ NAD⁺ supports cellular energy and repair. It drives ATP production, DNA repair, and mitochondrial resilience.
🛡️ Glutathione is the “protector.” It shields mitochondria from oxidative stress, recycles vitamins C and E, binds and eliminates toxins, and supports immune defenses.
Both are highly vulnerable to oxidative stress from mold, heavy metals, inflammation, lack of sleep, and alcohol. And both decline with age. When your NAD⁺ and GSH levels are depleted, you'll feel exhausted and foggy. When replete, you'll feel ready to take on the world!
Curiously, centenarians consistently show higher glutathione levels compared to those who experience age‑related diseases earlier in life. Human longevity data on NAD⁺ is still emerging.
But most importantly, glutathione and NAD⁺ work together. Glutathione maintains NAD⁺ in its active form, while NAD⁺ provides the energy for glutathione recycling. Deficiency in either disrupts the other.
The key distinction? NAD⁺ works intracellularly, while glutathione works both intra‑ and extracellularly, giving it a broader, more foundational role.
If you're prioritizing these molecules, start with glutathione. If you feel like you need more support, layer in NAD⁺. If you don't feel a difference with NAD+, then you probably don't need it (which is a good thing!).
Form matters:
Glutathione: best delivered via topicals, liposomal, or IV since oral GSH doesn’t absorb well. My go‑to is topical glutathione, which gets into the blood within 15 minutes.
NAD⁺: supplements have poor bioavailability, but nasal sprays, transdermal patches, and sub‑Q delivery ensure higher uptake.
Tap the link in my bio to explore these further.
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