Thomas Youm MD - Orthopaedic Surgeon

12/18/2025

Efficacy and Safety of Single Versus Repeated Injections of Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.

Both single and repeated MSC injections could improve pain and knee joint function in patients with KOA. Compared to single injections, repeated MSC injections may offer superior therapeutic benefits; however, they are associated with a higher incidence of adverse events. In clinical practice, poten...

11/27/2025

Wishing you and your family a wonderful Thanksgiving!

11/21/2025

Mesenchymal Stem Cells Injections in Traumatology and Orthopaedics: Common Practice or Still a Promising Area with Many Uncertainties?

MSC injections represent a growing area of research in traumatology and orthopaedics. However, the results of only a small proportion of clinical trials and systematic reviews are published in peer-reviewed journals, which most likely does not allow practitioners to form a full judgement on the effi...

11/12/2025

Ethical and Regulatory Considerations Related to Regenerative Medicine.

The application of stem cell therapies in orthopedics holds promise for the treatment of degenerative musculoskeletal conditions. Advances in cell sourcing, differentiation protocols, and delivery methods have brought the field closer to the point-of-care application of these therapies. Personalized...

11/11/2025

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10/24/2025

MXenzyme-Reinforced Hydrogel Enhances Stem Cell Therapy Through Multidimensional Regulation in Rheumatoid Arthritis Management.

Rheumatoid arthritis (RA) is a devastating autoimmune disorder that imposes health and economic burdens on communities worldwide. Although stem cell transplantation has emerged as a promising option for RA management, the osteoimmune microenvironment that characterizes elevated reactive oxygen/nitro...

10/17/2025

Stem Cell Discovery Could be Key to Tough-to-Fix Fractures.

When bones break and there is extreme tissue loss—such as after a car accident or a battlefield injury—current treatments don't often lead to effective healing. But certain stem cells from skeletal muscles can improve recovery by producing all the types of cells needed to heal bones.

10/13/2025

How small changes in walking technique may help treat knee osteoarthritis.

Gait analysis and pain measures show that subtly adjusting the angle of the foot during walking may reduce knee pain caused by osteoarthritis. This approach may also slow progression of the condition, an incurable disease in which the cartilage cushion inside a joint breaks down.

10/10/2025

Research Advances in Mesenchymal Stem Cells and Related Therapies for Rotator Cuff Tendon-to-Bone Healing.

Rotator cuff tears (RCTs) are a prevalent cause of shoulder dysfunction, with postoperative retearing remaining a significant challenge due to poor tendon-to-bone healing. Mesenchymal stem cells (MSCs), owing to their multipotency, immunomodulatory properties, and diverse tissue sources, have emerge...

10/06/2025

How to Get Rid of Sore Muscles: 10 Relief Tips.

It's common for your muscles to feel sore after a workout, particularly if it's a new exercise for you or a more intense session. Experts call this delayed-onset muscle soreness (DOMS), and it happens after physical activity that puts an unaccustomed load on your muscles. Whether muscle soreness is....

10/03/2025

XSTEM’s Knee Osteoarthritis Stem Cell Trial: Mid-Study Update, Safety and Positive Efficacy.

Xintela has released interim data from its ongoing clinical study evaluating its stem cell product, XSTEM, in patients with knee osteoarthritis. XSTEM is an allogeneic adipose stem cell therapy, consisting of integrin selected mesenchymal stem cells. At 18 months post-treatment, the company reports....

09/29/2025

8 Types of Shoulder Surgeries.

Common types of shoulder surgeries include rotator cuff repair, total shoulder replacement, and arthroscopy for conditions like frozen shoulder or impingement syndrome. In general, these and other shoulder procedures help treat shoulder injuries by repairing or replacing cartilage, tendons and ligam...