Thomas Youm MD - Orthopaedic Surgeon

02/09/2026

Stem Cell Pain Sponge Soaks up Osteoarthritis Joint Pain and Protects Cartilage.

SereNeuro Therapeutics revealed promising results for SN101, a first-in-class iPSC-derived therapy designed to treat chronic osteoarthritis pain while protecting joint tissue. Instead of blocking pain pathways, SN101 uses lab-grown nociceptors that act like sponges, soaking up inflammatory pain fact...

02/02/2026

Initial Safety Outcomes of Adipose-Derived Mesenchymal Stem Cell for Rotator Cuff Tear: A 3-Year Pilot Trial.

Injection of autologous MSCs derived from adipose tissue is safe in treating total rotator cuff tear. These findings support the initiation of larger-scale trials to further investigate the therapeutic potential and efficacy of MSCs in tendon regeneration.

01/23/2026

Regenerative Stem Cell Therapy: Good Alternative To Joint Replacement Surgery?

Stem cell therapy offers a minimally invasive alternative to joint replacement surgery, with recovery times of just one to two weeks compared to months for major surgery. Clinical studies show varying success rates, with 60-80% of patients in some trials experiencing significant pain relief and impr...

01/16/2026

Functionalized Mesenchymal Stem Cells for Enhanced Bone Regeneration: Advances and Challenges.

The functionalization of mesenchymal stem cells presents an exciting frontier in the field of bone regeneration therapies, with the potential to revolutionize current treatment strategies for bone defects and fractures. Significant advancements have been made through various techniques such as gene....

01/09/2026

Intra-Articular Delivery of Allogeneic Bone Marrow Derived Mesenchymal Stromal Cells (BM-MSCs) for Painful Lumbar Facet Arthropathy: A Phase I Clinical Trial.

This open-label, single-arm Phase I clinical trial demonstrated a favorable safety profile for intra-articular administration of allogeneic, culture-expanded BM-MSCs in the treatment of painful lumbar facet arthropathy. The manufacturing and delivery of the regimen were successful for all enrolled p...

12/18/2025

Efficacy and Safety of Single Versus Repeated Injections of Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.

Both single and repeated MSC injections could improve pain and knee joint function in patients with KOA. Compared to single injections, repeated MSC injections may offer superior therapeutic benefits; however, they are associated with a higher incidence of adverse events. In clinical practice, poten...

11/27/2025

Wishing you and your family a wonderful Thanksgiving!

11/21/2025

Mesenchymal Stem Cells Injections in Traumatology and Orthopaedics: Common Practice or Still a Promising Area with Many Uncertainties?

MSC injections represent a growing area of research in traumatology and orthopaedics. However, the results of only a small proportion of clinical trials and systematic reviews are published in peer-reviewed journals, which most likely does not allow practitioners to form a full judgement on the effi...

11/12/2025

Ethical and Regulatory Considerations Related to Regenerative Medicine.

The application of stem cell therapies in orthopedics holds promise for the treatment of degenerative musculoskeletal conditions. Advances in cell sourcing, differentiation protocols, and delivery methods have brought the field closer to the point-of-care application of these therapies. Personalized...

11/11/2025

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10/24/2025

MXenzyme-Reinforced Hydrogel Enhances Stem Cell Therapy Through Multidimensional Regulation in Rheumatoid Arthritis Management.

Rheumatoid arthritis (RA) is a devastating autoimmune disorder that imposes health and economic burdens on communities worldwide. Although stem cell transplantation has emerged as a promising option for RA management, the osteoimmune microenvironment that characterizes elevated reactive oxygen/nitro...

10/17/2025

Stem Cell Discovery Could be Key to Tough-to-Fix Fractures.

When bones break and there is extreme tissue loss—such as after a car accident or a battlefield injury—current treatments don't often lead to effective healing. But certain stem cells from skeletal muscles can improve recovery by producing all the types of cells needed to heal bones.