11/28/2025
“Why isn’t she waking up yet?”
The surgery went smoothly. The volatile agent is off. The vitals are stable. Yet the patient remains unresponsive. Vincent et al. 2025 explore actively facilitating emergence from general anesthesia, rather than waiting for passive drug clearance.
Three main strategies:
- Pharmacokinetic acceleration – speeding anesthetic elimination
- Direct receptor antagonism – blocking anesthetic binding sites
- Arousal circuit activation – engaging wake-promoting systems
These strategies make emergence as precise as induction.
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Vincent et al. Anesthesiology. 2025 Oct 1;143(4):1049-1089.