Weill Cornell GI Oncology Program

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Weill Cornell GI Oncology Program

Enabling patients across the entire spectrum of cancers of the digestive system to have the highest quality care and treatment.

As New York’s premier healthcare network, Weill Cornell Medicine is at the forefront of scientific research and clinical trials. The Gastrointestinal (GI) Oncology Program provides access to state-of-the-art treatments, offering patients the opportunity to receive treatments not available elsewhere. Our physicians, ranging from our medical oncologists, world-class surgical oncologists, gastroenterologists and radiation oncologists, use the approach of precision medicine, which provides individualized cancer treatment based on specific genetic vulnerabilities of each patient’s tumor. Gastrointestinal cancers include:

• Esophagus and gastro-esophageal cancers
• Pancreatic cancers
• Stomach (Gastric) cancers
• Colon cancers
• Re**al and a**l cancers
• Liver cancers
• Neuroendocrine cancers
• Gallbladder cancers
• Cancers of the small intestine
• Sarcomas, including GIST

Our page aims to provide you with the latest information and research developments.

03/12/2026

Dr. Rutika Mehta spoke with Targeted Oncology about a study looking at using circulating tumor DNA (ctDNA)-based minimal residual disease (MRD) testing in to help inform prognosis, treatment duration, toxicity, and potential treatment breaks:

ctDNA MRD testing may spot hidden relapse and guide treatment holidays in metastatic gastroesophageal cancer, as deep ctDNA drops predict longer PFS.

02/26/2026

12/23/2025

Dr. Rutika Mehta moderated a program to discuss results from a phase 3 evaluating a combination treatment regimen recently approved by the U.S. Food and Drug Administration for :

A panel of experts gathered to discuss results from the MATTERHORN trial assessing durvalumab plus FLOT in gastric/GEJ cancer.

12/11/2025

Watch Dr. Despina Siolas provide insights into the important we’re doing Weill Cornell Medicine to find ways to personalize treatment:

Dr. Despina Siolas, assistant professor of medicine at Weill Cornell Medicine, is working to personalize treatment for pancreatic cancer and develop new therapeutic regimens that save more patient lives.

10/29/2025

WATCH: Dr. Rutika Mehta discusses targeted approaches to biomarker testing for patients with upper gastrointestinal ( ) malignancies:

Rutika Mehta, MD, MPH, discusses targeted approaches to biomarker testing for patients with upper gastrointestinal malignancies.

09/23/2025

Dr. Despina Siolas spoke with Women's Health about potential symptoms that shouldn’t be ignored as part of an article on when to see a doctor for health concerns:

Beyond the expected ones.

04/10/2025

Join us in our social media welcome for GI medical oncologist Dr. Rutika Mehta! Dr. Mehta is available for appointments for patients with all types of : https://bit.ly/42WsKkm

03/25/2024

Dr. Manish Shah breaks down everything patients should know about , including common symptoms, arriving at a diagnosis, and the latest treatments. Read more via NewYork-Presbyterian Hospital:

A medical oncologist explains the symptoms of stomach cancer, how it’s diagnosed, and the latest treatments.

03/21/2024

A recent study led by Dr. Pashtoon Kasi evaluating two next-generation drugs shows promising activity against Stage IV when there are no tumors in the liver:

Giving two immunotherapy drugs before surgery to remove colorectal cancer shows highly promising results

10/02/2023

led by Dr. Pashtoon Kasi showed that giving early-stage patients an investigational prior to surgery could have promising results: https://bit.ly/3ZQRKWR (cc: Forbes)

A combination immunotherapy developed by biotech company Agenus administered before surgery destroyed over 80% of a tumor before it was removed.

06/23/2023

05/19/2023

Dr. Manish Shah spoke with Medpage Today about the new ASCO guidelines on advanced . He was also part of the expert panel that developed these guidelines:

Recommendations for use of immunotherapy and targeted therapy

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1305 York Avenue
New York, NY
10021

Telephone

(646) 962-6200

Website

https://weillcornell.org/gicancer

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Dr. Paul Gregory, DDS
57 W 57th Street
Magnus Wellness
16 E 40th Street, Fl 4

Our Story

The Gastrointestinal (GI) Oncology Program at Weill Cornell Medicine and NewYork-Presbyterian is dedicated to providing state-of-the-art personalized care across the entire spectrum of cancers of the digestive system.

Our team works relentlessly to improve the lives of people with gastrointestinal cancer. We pride ourselves on putting patients first, tailoring treatment to each individual’s unique needs in order to maximize health outcomes and minimize potential side effects of therapy.