Weill Cornell GI Oncology Program

Weill Cornell GI Oncology Program Enabling patients across the entire spectrum of cancers of the digestive system to have the highest quality care and treatment.

As New York’s premier healthcare network, Weill Cornell Medicine is at the forefront of scientific research and clinical trials. The Gastrointestinal (GI) Oncology Program provides access to state-of-the-art treatments, offering patients the opportunity to receive treatments not available elsewhere. Our physicians, ranging from our medical oncologists, world-class surgical oncologists, gastroenterologists and radiation oncologists, use the approach of precision medicine, which provides individualized cancer treatment based on specific genetic vulnerabilities of each patient’s tumor. Gastrointestinal cancers include:

• Esophagus and gastro-esophageal cancers
• Pancreatic cancers
• Stomach (Gastric) cancers
• Colon cancers
• Re**al and a**l cancers
• Liver cancers
• Neuroendocrine cancers
• Gallbladder cancers
• Cancers of the small intestine
• Sarcomas, including GIST

Our page aims to provide you with the latest information and research developments.

In another Targeted Oncology interview, Dr. Rutika Mehta talks about   gaps that should be addressed before circulating ...
04/02/2026

In another Targeted Oncology interview, Dr. Rutika Mehta talks about gaps that should be addressed before circulating tumor DNA (ctDNA) testing is more widely integrated into standard of care for patients:

New study signals ctDNA MRD clearance and 90% drops predict better gastroesophageal cancer outcomes, fueling calls for prospective trials.

March is  . Did you know that mismatch repair-deficient   has unique traits that change how it responds to treatment? Dr...
03/31/2026

March is . Did you know that mismatch repair-deficient has unique traits that change how it responds to treatment? Dr. Manish Shah spoke with two experts on the CancerCast podcast about how immunotherapy and genetic testing for are changing outcomes for people with this form of and who are most at risk for developing it. Listen to the episode: https://bit.ly/4hyecwH

Hosted by Dr. Manish Shah, Chief of the Soid Tumor Oncology Program Weill Cornell Medicine, the CancerCast podcast offer...
03/30/2026

Hosted by Dr. Manish Shah, Chief of the Soid Tumor Oncology Program Weill Cornell Medicine, the CancerCast podcast offers conversations designed to support, inform, and empower people living with cancer, their loved ones, and caregivers. Each episode features in depth discussions with leading experts who help break down complex advances in cancer diagnosis, treatment, and research. Recent topics explore cutting edge technologies and breakthroughs across many types of cancer. Tune in and subscribe to stay informed about the innovations and insights shaping the future of cancer care.

Listen to the episodes on Apple Podcasts (https://bit.ly/40IugnI), Spotify (https://bit.ly/47r9c94), YouTube (https://bit.ly/4nRMEon), or at weillcornell.org/cancercast.

From  : Dr. Rutika Mehta talked with Oncology Learning Network about reintroducing   after previously stopping it for pa...
03/30/2026

From : Dr. Rutika Mehta talked with Oncology Learning Network about reintroducing after previously stopping it for patients with /

Rutika Mehta, MD, discusses whether immunotherapy rechallenge should be considered for patients with esophageal and gastric cancers.

In this interview with Targeted Oncology, Dr. Rutika Mehta outlines what clinicians should know when deciding to use cir...
03/26/2026

In this interview with Targeted Oncology, Dr. Rutika Mehta outlines what clinicians should know when deciding to use circulating tumor DNA (ctDNA) or minimal residual disease (MRD) testing to manage patients:

Learn how ctDNA/MRD testing guides gastroesophageal cancer care—patient counseling, coverage hurdles, and what rising ctDNA means before scans.

ICYMI: Dr. Rutika Mehta spoke with Targeted Oncology about the role of circulating tumor DNA (ctDNA) to improve early de...
03/19/2026

ICYMI: Dr. Rutika Mehta spoke with Targeted Oncology about the role of circulating tumor DNA (ctDNA) to improve early detection of recurrence in .

ctDNA MRD monitoring may augment scans and tumor markers, enabling earlier detection of gastroesophageal cancer recurrence, especially hard-to-image peritoneal relapse.

Dr. Rutika Mehta spoke with Targeted Oncology about a study looking at using circulating tumor DNA (ctDNA)-based minimal...
03/12/2026

Dr. Rutika Mehta spoke with Targeted Oncology about a study looking at using circulating tumor DNA (ctDNA)-based minimal residual disease (MRD) testing in to help inform prognosis, treatment duration, toxicity, and potential treatment breaks:

ctDNA MRD testing may spot hidden relapse and guide treatment holidays in metastatic gastroesophageal cancer, as deep ctDNA drops predict longer PFS.

02/26/2026
Dr. Rutika Mehta moderated a program to discuss results from a phase 3   evaluating a combination treatment regimen rece...
12/23/2025

Dr. Rutika Mehta moderated a program to discuss results from a phase 3 evaluating a combination treatment regimen recently approved by the U.S. Food and Drug Administration for :

A panel of experts gathered to discuss results from the MATTERHORN trial assessing durvalumab plus FLOT in gastric/GEJ cancer.

Watch Dr. Despina Siolas provide insights into the important   we’re doing Weill Cornell Medicine to find ways to person...
12/11/2025

Watch Dr. Despina Siolas provide insights into the important we’re doing Weill Cornell Medicine to find ways to personalize treatment:

Dr. Despina Siolas, assistant professor of medicine at Weill Cornell Medicine, is working to personalize treatment for pancreatic cancer and develop new therapeutic regimens that save more patient lives.

WATCH: Dr. Rutika Mehta discusses targeted approaches to biomarker testing for patients with upper gastrointestinal ( ) ...
10/29/2025

WATCH: Dr. Rutika Mehta discusses targeted approaches to biomarker testing for patients with upper gastrointestinal ( ) malignancies:

Rutika Mehta, MD, MPH, discusses targeted approaches to biomarker testing for patients with upper gastrointestinal malignancies.

Dr. Despina Siolas spoke with Women's Health about potential   symptoms that shouldn’t be ignored as part of an article ...
09/23/2025

Dr. Despina Siolas spoke with Women's Health about potential symptoms that shouldn’t be ignored as part of an article on when to see a doctor for health concerns:

Beyond the expected ones.

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Our Story

The Gastrointestinal (GI) Oncology Program at Weill Cornell Medicine and NewYork-Presbyterian is dedicated to providing state-of-the-art personalized care across the entire spectrum of cancers of the digestive system.

Our team works relentlessly to improve the lives of people with gastrointestinal cancer. We pride ourselves on putting patients first, tailoring treatment to each individual’s unique needs in order to maximize health outcomes and minimize potential side effects of therapy.