TGen

TGen TGen (Translational Genomics Research Institute) is a nonprofit biomedical research institute What is new and noteworthy in genomics?

What sorts of discoveries are coming from our laboratories in Phoenix, Scottsdale and Flagstaff, as well as our national and international collaborations? Find out by following us on this and all social channels:
- Twitter: https://twitter.com/TGen
- LinkedIn: https://www.linkedin.com/company/tgen

✨1️⃣✨ Pinpointing Where Molecular Changes BeginThe #1 most viewed post of 2025 details a study published in Cell Report...
12/31/2025

✨1️⃣✨ Pinpointing Where Molecular Changes Begin

The #1 most viewed post of 2025 details a study published in Cell Reports Medicine that uncovered important molecular signatures that could help predict the progression of hepatic steatosis, a liver condition linked to obesity and other metabolic disorders. Using single-cell and spatial transcriptomics, researchers also mapped where molecular changes occur inside the liver, providing insights into potential disease mechanisms, paving the way for earlier detection, improved monitoring, and targeted therapies.

🔗 https://bit.ly/3DpGgCj

2️⃣ Blood-based test detects precancerous colorectal lesions Coming in at #2 is a study from City of Hope, Johns Hopkin...
12/30/2025

2️⃣ Blood-based test detects precancerous colorectal lesions

Coming in at #2 is a study from City of Hope, Johns Hopkins University, University of Pittsburgh and TGen that details promising ways to detect adenomas (precancerous polyps) using cell-free DNA from a simple liquid biopsy (a blood test). They found that DNA fragmentation analysis, a method called fragmentomics, delivered the most accurate results for early-stage detection.

🔗 https://bit.ly/3M0t8I9

3️⃣ New hope for lung cancer patientsLanding in the #3 spot is a study by TGen and Baylor Scott & White researchers who...
12/29/2025

3️⃣ New hope for lung cancer patients

Landing in the #3 spot is a study by TGen and Baylor Scott & White researchers who report on a potential therapeutic strategy that uses the body’s own natural killer (NK) cells to fight hard-to-treat lung cancers. Published in Frontiers in Immunology, their findings suggest NK cell–derived vesicles may reignite the immune system and attack resistant tumors. View the release here.

🔗 https://bit.ly/44tyQZp

4️⃣ A Spatial Map of Gene Expression in Pulmonary Fibrosis Claiming the #4 spot is research from TGen led by Annika Va...
12/28/2025

4️⃣ A Spatial Map of Gene Expression in Pulmonary Fibrosis

Claiming the #4 spot is research from TGen led by Annika Vannan, Ph.D., published in Nature Genetics, revealing hidden disease markers in seemingly healthy lung tissue through advanced spatial transcriptomics. Could this breakthrough pave the way for earlier, more personalized treatments? Hear more on Episode 80 of TGen Talks as Nicholas Banovich, Ph.D., explains the findings and their potential impact on the future of lung disease research.

🔗 Link to the Nature Genetics paper: https://bit.ly/3EApIrK

🔗 Link to podcast: https://bit.ly/48hug1w

5️⃣ Could “Zombie” Cells Offer New Hope for Pancreatic Cancer Treatment?An NIH grant is supporting TGen’s work on a new ...
12/27/2025

5️⃣ Could “Zombie” Cells Offer New Hope for Pancreatic Cancer Treatment?

An NIH grant is supporting TGen’s work on a new treatment approach for pancreatic ductal adenocarcinoma (PDAC), a highly aggressive cancer with just a 13% five-year survival rate. The project targets senescent “zombie” cells—damaged cells that linger in the tumor environment. Researchers are testing SIWA318, a novel antibody designed to eliminate these cells in advanced PDAC models. Early results show reduced tumor growth and stronger immune activity. It’s #5 on our most viewed of 2025.

🔗 https://bit.ly/3WZeZOa

6️⃣ AI Breakthrough in Cancer Genomics #6 on our list is a Nature Biotechnology study introducing DeepSomatic, a new mac...
12/26/2025

6️⃣ AI Breakthrough in Cancer Genomics

#6 on our list is a Nature Biotechnology study introducing DeepSomatic, a new machine-learning method that greatly improves the detection of cancer-related genetic mutations. Developed by UC Santa Cruz Genomics Institute and Google Research, with contributions from TGen’s Floris Barthel, M.D., Ph.D., the tool enhances identification of somatic variants — mutations acquired during life that often fuel tumor growth.

🔗 View the release here: https://bit.ly/4nYDDJY

12/25/2025

Wishing you a holiday filled with joy and memories. We hope you have a wonderful holiday ❤️🎄💚✨

7️⃣ Researchers identify a potential biomarker for long COVIDLucky #7 is a study that identified a potential biomarker ...
12/25/2025

7️⃣ Researchers identify a potential biomarker for long COVID

Lucky #7 is a study that identified a potential biomarker for long COVID. If the findings, published in the journal Infection, are confirmed by other research centers, the biomarker could be the first specific and quantifiable indicator for confirming long COVID.

🔗 View the release here: https://bit.ly/3JX7ofN

8️⃣ The Promise of Liquid BiopsyHolding down the #8 spot is Episode 86 of TGen Talks with Dr. Floris Barthel, Dr. Shea ...
12/24/2025

8️⃣ The Promise of Liquid Biopsy

Holding down the #8 spot is Episode 86 of TGen Talks with Dr. Floris Barthel, Dr. Shea Gallus, and graduate student Sharvari Mankame to discuss their work on using a simple blood or spinal fluid sample to detect and monitor brain cancer, potentially reducing the need for invasive surgery. They explain how AI is helping them analyze tumor DNA and track cancer in real-time.

🔗 Link to listen to the podcast: https://bit.ly/48vEbBQ

12/23/2025

🎄 ✨ 🎁 🎶 ❤️
We took a moment to be present as an organization, celebrating the work we have accomplished together and the work we hope to achieve in the upcoming years.

Thank you to all who make our organization continue to innovate and work towards improving cancer detection, treatment and care for all.

9️⃣ What’s Really Lurking in Your Lawn?Did you know your w**d killer might be doing more than tidying your yard? At #9,...
12/23/2025

9️⃣ What’s Really Lurking in Your Lawn?

Did you know your w**d killer might be doing more than tidying your yard? At #9, the highlights of a TGen-Arizona State University study showing that glyphosate, a common herbicide chemical, can cross the blood-brain barrier and may cause lasting damage long after exposure. On Episode 77 of TGen Talks, Patrick Pirrotte, Ph.D., shares how glyphosate triggers neuroinflammation and accelerates Alzheimer’s-like changes, raising important questions about what levels are truly safe.

🔗 Link to study: https://bit.ly/4821VgV

🔗 Link to listen to the podcast: https://bit.ly/3XTUr9z

1️⃣ 0️⃣ The Power of NanotherapeuticsBreaking in at the #10 spot is Episode 78 of TGen Talks. TGen’s John Fryer, Ph.D.,...
12/22/2025

1️⃣ 0️⃣ The Power of Nanotherapeutics

Breaking in at the #10 spot is Episode 78 of TGen Talks. TGen’s John Fryer, Ph.D., introduces us to nanotherapeutics, a revolutionary approach using ultra-small molecules called nanobodies to tackle diseases once thought untreatable. These tiny powerhouses are 10 times smaller than traditional antibodies, allowing them to pe*****te the incredibly intricate brain barrier more readily and his research offers great potential for treating neurodegenerative diseases and more.

🔗 Link to listen to the podcast: https://bit.ly/4psDkHN

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