TGen

TGen TGen (Translational Genomics Research Institute) is a nonprofit biomedical research institute What is new and noteworthy in genomics?

What sorts of discoveries are coming from our laboratories in Phoenix, Scottsdale and Flagstaff, as well as our national and international collaborations? Find out by following us on this and all social channels:
- Twitter: https://twitter.com/TGen
- LinkedIn: https://www.linkedin.com/company/tgen

1️⃣ 2️⃣ Finding Answers in the Gray Areas of Genetic Testing When a child shows signs of developmental delay, obtaining ...
12/20/2025

1️⃣ 2️⃣ Finding Answers in the Gray Areas of Genetic Testing

When a child shows signs of developmental delay, obtaining a clear diagnosis turns challenging when standard genetic testing returns mixed results. At #12, a study led by Vinodh Narayanan, M.D., medical director of TGen's Center for Rare Childhood Disorders, suggests epigenetic testing as a powerful diagnostic tool that provides more definitive answers by allowing clinicians to move from uncertainty toward action.

🔗 to the journal: https://bit.ly/4piFNoN

1️⃣ 3️⃣ From Deadly to Detectable?Our #13 post of the year, but certainly not unlucky, is Episode 87 of TGen Talks, whe...
12/19/2025

1️⃣ 3️⃣ From Deadly to Detectable?

Our #13 post of the year, but certainly not unlucky, is Episode 87 of TGen Talks, where Haiyong Han, Ph.D., explores why pancreatic cancer is so difficult to detect early. He explains how the disease can grow silently for years, why finding true positives in the general population is challenging, and what his team is doing to change that. Dr. Han also shares progress on a promising non-invasive screening test that could enable earlier detection, with the ultimate goal of turning this deadly cancer into a more manageable condition and offering patients real hope.

Click the 🔗 to listen: https://bit.ly/3XLuAkb

1️⃣ 4️⃣ New biomarkers for pancreatic cancer?At #14, research co-led by TGen’s Haiyong Han, Ph.D., identifying two prot...
12/18/2025

1️⃣ 4️⃣ New biomarkers for pancreatic cancer?

At #14, research co-led by TGen’s Haiyong Han, Ph.D., identifying two protein biomarkers (ALPPL2 and THBS2), that can accurately detect pancreatic cancer from a simple blood test. Found in exosomes, these markers outperform CA19-9, which misses nearly 20% of patients. Published in the British Journal of Cancer, this non-invasive approach could transform early detection and monitoring of a cancer often found too late.

🔗 https://bit.ly/4mbboX0

1️⃣ 5️⃣ A Cellular Map of the Infant Lung #15 explains how a TGen-led team has built a high-resolution spatial atlas of ...
12/17/2025

1️⃣ 5️⃣ A Cellular Map of the Infant Lung

#15 explains how a TGen-led team has built a high-resolution spatial atlas of the developing human lung, revealing how more than one million cells grow, interact, and organize to enable healthy breathing. Using image-based spatial transcriptomics, researchers pinpointed where key cellular and molecular events occur during development. The map offers new insights that could guide future diagnostics and therapies for vulnerable newborns. Find the paper at the link below.

🔗 https://bit.ly/49DXyKe

12/16/2025

As part of City of Hope, TGen is proud to help drive the future of cancer research and care. City of Hope’s 2026 predictions reflect the power of genomics, innovation and teamwork — personalized therapies, nutrition-powered treatments, outpatient cell therapies treatments, AI-driven care and smarter clinical trial access.

TGen scientists and clinicians are working alongside City of Hope colleagues to turn these predictions into reality. Together, we’re advancing precision medicine and making breakthroughs accessible to patients in Arizona and beyond. Read the full story: https://www.cityofhope.org/about-city-of-hope/newsroom/2026-predictions

#2026

1️⃣ 6️⃣ Immunotherapies for Ovarian CancerLanding at #16, our story on a TGen led study that suggests faulty gene splic...
12/16/2025

1️⃣ 6️⃣ Immunotherapies for Ovarian Cancer

Landing at #16, our story on a TGen led study that suggests faulty gene splicing in a rare ovarian cancer, SCCOHT, may make these aggressive tumors responsive to immunotherapy. Driven by loss of a key protein, SMARCA4, the cancer cells mishandle RNA and fail to remove non-coding segments called introns, creating abnormal proteins that flag tumor cells as foreign. The findings point toward more targeted immune-based treatments for patients with this devastating cancer.

🔗 https://bit.ly/4p2sBEe

Applications are open!About the Helios Scholars at TGen program:📆 8 weeks💰Paid internship🤝 Daily mentorship🗣️ Complete...
12/15/2025

Applications are open!

About the Helios Scholars at TGen program:
📆 8 weeks
💰Paid internship
🤝 Daily mentorship
🗣️ Complete the program with a poster symposium

Are you a:
🎂 At least 16 years old by June 8, 2026
🎓 A full-time college/university student for Fall 2026 (undergraduate, graduate, and medical students eligible!)
🌵 A graduate of an AZ High school by June 8 OR attending an Arizona college or University
☀️ Available June 8 – July 31

More at tgen.org/helios

TGen Bioscience Leadership Academy (TBLA) Applications are open! 📆 2 weeks 💰Receive a $1,000 scholarship 🤝 Learn from T...
12/15/2025

TGen Bioscience Leadership Academy (TBLA) Applications are open!

📆 2 weeks
💰Receive a $1,000 scholarship
🤝 Learn from TGen scientists and staff

Are you a:
🎂 At least 16 years old by June 15, 2026
🌵 A rising junior or senior at an Arizona high school
☀️ Available June 15 – 26

More at tgen.org/tbla

1️⃣ 7️⃣ Hope Arrives in North Scottsdale #17 on our list is a story on City of Hope Phoenix (COH) opening its new, state...
12/15/2025

1️⃣ 7️⃣ Hope Arrives in North Scottsdale

#17 on our list is a story on City of Hope Phoenix (COH) opening its new, state-of-the-art Scottsdale center at One Scottsdale Medical. The 30,000 square foot facility brings world-class oncology care closer to the communities COH serves and strengthens its collaboration with TGen, speeding breakthroughs from research to patients and expanding access to personalized cancer care across the region.

🔗 https://bit.ly/4rjxvhu

1️⃣ 8️⃣ When Healthy Weight Hides a RiskAt #18, a cautionary tale on how looks can be deceiving. In this case, how even...
12/14/2025

1️⃣ 8️⃣ When Healthy Weight Hides a Risk

At #18, a cautionary tale on how looks can be deceiving. In this case, how even people at a healthy weight can carry genetic variants that drive liver fat buildup. Published in JHEP Reports, the study spotlights overlooked genetic factors tied to MASLD and its more severe form, MASH, revealing that the disease is far more complex than its relationship with body mass index (BMI).

🔗 https://bit.ly/3YURmas

1️⃣ 9️⃣ A Summer at TGenComing in at #19 is Episode 83 of TGen Talks where 2025 Helios Education Foundation Scholar at ...
12/13/2025

1️⃣ 9️⃣ A Summer at TGen

Coming in at #19 is Episode 83 of TGen Talks where 2025 Helios Education Foundation Scholar at TGen, Audra Welch, breaks down her summer of science and highlights TGen’s supportive, discovery-focused environment, where curiosity meets drive and the next generation of researchers flourish under the guidance of a TGen mentor.

Listen to the podcast: https://www.tgen.org/tgen-talks/episode-83-discovering-a-future-in-science-the-helios-scholars-at-tgen-program/

Learn more about the Helios Scholars at TGen: https://www.tgen.org/helios Applications open Dec. 12 for the 20th summer cohort.

2️⃣ 0️⃣ Sekulic Named Physician-in-ChiefKicking off our countdown is TGen’s announcement naming Aleksandar Sekulic, M.D....
12/12/2025

2️⃣ 0️⃣ Sekulic Named Physician-in-Chief

Kicking off our countdown is TGen’s announcement naming Aleksandar Sekulic, M.D., Ph.D., as its new Physician-in-Chief. A nationally recognized leader in skin cancer research and treatment, Dr. Sekulic brings deep expertise in immunotherapy, targeted therapies, and precision medicine. His career has driven FDA-approved breakthroughs and advanced compassionate, individualized care for patients with complex skin cancers.

🔗 https://bit.ly/4a5TQsP

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