Center for Complex Neurology, EDS & POTS

Center for Complex Neurology, EDS & POTS The office of David Saperstein, MD. We specialize in EDS, POTS and other disorders of nerve, muscle
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🔬 Cranial Cervical Instability (CCI) is a medical condition that occurs when the ligaments and connective tissues that s...
03/25/2026

🔬 Cranial Cervical Instability (CCI) is a medical condition that occurs when the ligaments and connective tissues that support the head and neck become weakened or damaged. This can lead to excessive movement between the skull and the upper cervical spine, causing a variety of symptoms such as chronic headaches, neck pain, vertigo, and even cognitive impairment. 🧠

🔗 CCI is often seen in individuals with conditions such as Ehlers-Danlos Syndrome but can also be caused by trauma or degenerative changes in the spine. Treatment for CCI may include physical therapy, medication, or in severe cases, surgery.

💬What's the most frustrating thing about CCI? Tell us in the comments. 👇
🔁 Share this post to spread awareness.
📲 Visit our website to learn more.
https://bit.ly/CranialCervicalInstability

✨ WHAT IS HSD?! 🤔Most people are told it’s “just flexibility.”But HSD can involve pain, instability, fatigue, and sympto...
03/24/2026

✨ WHAT IS HSD?! 🤔
Most people are told it’s “just flexibility.”

But HSD can involve pain, instability, fatigue, and symptoms that affect more than just joints.

For many, it’s not mild.
It’s daily, complex, and often misunderstood.

If this sounds familiar, you’re not alone.

Drop a 🦓 if you have ever been told, “You’re just double-jointed.”
📌 Save this post to reference later
📤 Share to raise awareness

Learn more about what our Center has to offer. https://bit.ly/LearnMore_EDS

Long COVID is not always linear.Symptoms can come and go, change over time, and affect people in very different ways, so...
03/23/2026

Long COVID is not always linear.

Symptoms can come and go, change over time, and affect people in very different ways, sometimes lasting months or even years.

For some, this goes beyond discomfort and can impact daily function and quality of life.

This is why awareness matters.
This is why patients need to be taken seriously.

🔗 Learn more about Long COVID
Check out Dr. Saperstein’s videos. https://bit.ly/LONG-COVID

💬 Do you think Long COVID is still being misunderstood?
🔁 Share this to help others understand
💾 Save this for future reference

Most people think it’s “just dizziness.”It’s not.POTS affects how the body regulates heart rate and blood flow when stan...
03/21/2026

Most people think it’s “just dizziness.”
It’s not.

POTS affects how the body regulates heart rate and blood flow when standing and for many, it impacts every part of daily life.

From fatigue… to brain fog… to feeling worse just being upright,
these symptoms are often misunderstood or dismissed.

💬 What symptom affects you the most?
👇 Comment below

📌 Save this to come back to later.
📧 Share to help others understand POTS.
📲 Visit our website to learn more.
https://bit.ly/POTSandDysautonomia

Did you know some of the Top Causes of CCI include:🧬 Ehlers-Danlos Syndrome (EDS)🚗 Trauma or Whiplash🦴 Rheumatoid Arthri...
03/19/2026

Did you know some of the Top Causes of CCI include:
🧬 Ehlers-Danlos Syndrome (EDS)
🚗 Trauma or Whiplash
🦴 Rheumatoid Arthritis
🏥 Previous Neck or Chiari Surgery

CCI (Cranial Cervical Instability) occurs when the ligaments and structures that support the skull and upper spine become too weak or damaged, leading to serious neurological and vascular symptoms that often go overlooked.

✨ Awareness saves lives. Many people live years without answers, and early recognition can make all the difference.

💬 Have you or someone you know been impacted by CCI?
⬇️ Drop a 💙 in the comments to show support
🔁 Share this post to spread awareness
📌 Save for later
❤️ Like to help this reach more people

💭 Brain fog isn’t just about feeling tired, it’s often a sign of an underlying health condition. Dysautonomia, Mast Cell...
03/17/2026

💭 Brain fog isn’t just about feeling tired, it’s often a sign of an underlying health condition. Dysautonomia, Mast Cell Activation Syndrome, and even gut health can play a role!

🧠 Swipe through to learn what causes brain fog and how to manage it!

💬 Have you experienced brain fog? Drop a 💭 in the comments!

For the first time since 2017, the diagnostic criteria for Ehlers-Danlos syndromes (EDS) and Hypermobility Spectrum Diso...
03/16/2026

For the first time since 2017, the diagnostic criteria for Ehlers-Danlos syndromes (EDS) and Hypermobility Spectrum Disorders (HSD) are being updated.

The new framework is expected to be published December 1, 2026 in the peer-reviewed journal, American Journal of Medical Genetics Part C: Seminars in Medical Genetics.

The publication will outline the updated classification of EDS types, revised diagnostic criteria, and an updated framework for HSD to guide clinicians.

A second publication in March 2027 is expected to provide best-practice care and management pathways.

Do you think the diagnostic criteria should be updated?
⬜ Yes
⬜ No

🚨 Chronic Pain Check-In! 🚨Chronic pain is a constant battle for many dealing with neurological disorders. 💭How’s everyon...
03/15/2026

🚨 Chronic Pain Check-In! 🚨

Chronic pain is a constant battle for many dealing with neurological disorders. 💭

How’s everyone feeling on the pain scale today? 🧠💥

💧 Reminder: Stay hydrated! Dehydration pulls fluid out of your tissues, which can cause body aches and pains. One way to reduce pain is to increase your daily intake of water. 💦

✨Drop a 💙 in the color that represents your

03/13/2026

Mast cells.
You’ve probably heard the term… but what do they actually do?

In this reel, Dr. David Saperstein explains the role mast cells play in your immune system and why they’re found in key areas of the body like your skin, airways, sinuses, and digestive tract.

These cells act like your body’s first line of defense. When something harmful enters the body, mast cells release chemicals like histamine to trigger inflammation and recruit the immune system to respond.

But when mast cells overreact or malfunction, that response can lead to allergies, hives, rashes, and other symptoms.

Understanding mast cells is an important piece of understanding conditions like Mast Cell Activation Syndrome (MCAS) and other complex disorders.

Watch the full explanation from Dr. Saperstein.

💬 What symptoms made you realize mast cells might be involved?
💾 Save this to reference later
🔁 Share with someone trying to understand mast cells

🔬 Patients with MCAS (Mast Cell Activation Syndrome) may experience numerous symptoms, which can significantly disrupt d...
03/12/2026

🔬 Patients with MCAS (Mast Cell Activation Syndrome) may experience numerous symptoms, which can significantly disrupt daily life. This activation can impact several organ systems, including the respiratory, cardiovascular, skin, gastrointestinal, musculoskeletal, and nervous systems. The graphic provides examples of potential effects associated with different MCAS mediators.

Please note: This list is not comprehensive and serves only as an example. Mast cells secrete a range of mediators that lead to numerous symptoms across various organ systems.

MCAS can be hard to diagnose. There are blood and urine tests, but these are frequently normal. The symptoms of MCAS can often be brought under control through the use of antihistamines, mast cell stabilizers, and other medications.

🩺 Dr. David Saperstein worked with a group of mast cell activation specialists, led by Dr. Lawrence Afrin to propose new diagnostic criteria to update a Diagnosis Journal first published on January 22, 2014. This journal is called Diagnosis of Mast Cell Activation Syndrome: a Global “Consensus-2”.

Visit our website to learn more about MCAS now.
https://bit.ly/LearnMoreAbout_MCAS

Most people think Long COVID is just fatigue.But many patients experience symptoms affecting multiple systems in the bod...
03/11/2026

Most people think Long COVID is just fatigue.

But many patients experience symptoms affecting multiple systems in the body.
🔴 Brain
🔴 Lungs
🔴 Autonomic nervous system
🔴 Digestive system
🔴 Muscles & joints
🔴 Energy regulation

Symptoms can include:
🔹 Brain fog
🔹 Dizziness when standing
🔹 Rapid heart rate (palpitations)
🔹 Shortness of breath
🔹 Muscle and joint pain
🔹 Fatigue that worsens after physical or mental effort

For some people, these symptoms persist for months or longer after infection.

Long COVID is complex and often misunderstood.

💬 Which symptom that impacts you the most.

💾 Save this post to reference later
📤 Share this to raise awareness about Long COVID

03/11/2026

The Trifecta by Dr. David Saperstein

Many patients with complex autonomic and connective tissue disorders don’t experience just one condition in isolation. Instead, they may have a combination of Ehlers-Danlos Syndrome (EDS)/Hypermobility, POTS/Dysautonomia, and Mast Cell Activation Syndrome (MCAS).

This overlap is often referred to as “the trifecta.” These conditions frequently occur together, influence one another, and can make diagnosis and treatment more complex. Understanding how they intersect is an important step toward better recognition and care.

▶️ Watch as Dr. Saperstein explains the connection.

💙 Do you have EDS/Hypermobility, POTS/Dysautonomia, MCAS, or all three? Comment below.
💙 Save this to reference later.
💙 Share with someone trying to understand their symptoms.
💙 Follow for more expert insights on complex neurological and autonomic conditions.

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Address

1010 E McDowell Road. , Suite 101
Phoenix, AZ
85006

Opening Hours

Monday 8am - 4pm
Tuesday 8am - 4pm
Thursday 8am - 4pm
Friday 8am - 4pm

Telephone

+16029009404

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Center for Complex Neurology

We provide expert diagnosis and treatment of selected diseases, to include ALS, CIDP, Ehlers-Danlos Syndrome, (EDS), GBS, Neuropathy, Myositis, Muscular Dystrophy, Myasthenia Gravis, POTS & other dysautonomias. Dr. Saperstein has over 20 years of experience diagnosing, treating and researching these conditions.

Why did I create the Center for Complex Neurology?

Over the last 22 years I have been practicing medicine I have done so in a variety of settings: on staff at a university medical center, in private practice, as part of a health care system, and even in the U.S. military (Air Force). Each system had it pluses and minuses. But all forms of medical practice have come under strain in recent years from unprecedented changes in the health care system.