10/03/2023
Why have I watched the sunrise every day for an hour over the last 6 months and spent as much time in the mid-day sun as possible even with a history of SCC in situ.
“dietary vitamin D supplements alone cannot compensate for the lack of sunlight. Any dermatologist who tells you this is committing malpractice, in my view. We now need cardiologists to reject the "dermatologist evidence" about the sun to look at the relative risks of heart disease and skin cancer in people who have received different amounts of sun exposure. Black swans know it will confirm that sunlight reduces the death rate from all causes because many other studies have already shown the effects. Humans who understand light will need to reject the medical paradigm's version of evidence because it is now crystal clear we ALL need to reconsider "the professional advice" that has been given on sun exposure as a falsehood misunderstood based on things never considered in the original studies done in the 1950s in dermatology.”
TODAY'S LESSON COMES FROM AN ANSWER ON MY PATREON BLOG. You should read what I lay down on Patreon, folks. For the cost of a cup of coffee a month, you get to rent my brain and read what it knows.
DNA microarray technology has become useful for evaluating global gene expression in UV-irradiated cells. What these studies have shown, however, has revealed that the belief that UV only hurts biology is dead wrong. 2 examples are as follows:
1. UV radiation induces the clustering of specific cell-surface receptors. It leads to the formation of GOOD reactive oxygen species (ROS), which result in the signal transduction of cell survival and proliferation.
2. UV radiation activates ATR-targeting proteins that directly contribute to the cell cycle checkpoint control and repair system, mainly in the S-phase. Upon UV irradiation in mammalian cells, ATR/CHK1 is activated, resulting in the phosphorylation of p53, leading to the transactivation of various p53-responsive genes. The p53-responsive genes, such as p21, are essential in cell cycle regulation to control apoptosis in mitochondria. The radiation of UV light controls human apoptosis decision-making.
This photocontrol system either sustains the UV-damaged cell or protects the UV-damaged individuals by inducing apoptosis of cells that are too severely damaged to be repaired. This is critical in avoiding cancers and not causing them. UV light completely controls the circadian clock transcriptome.
Let that FACT sink in deeply. Centralized experts are not experts in what matters. They are experts in the superfluous. Ultraviolet (UV) radiation of ANY TYPE induces various biological positive effects. When researchers performed transcriptome analysis using a microarray in human primary cultured fibroblasts irradiated with UV-C frequencies with a power density of 0.5 or 5 J/m2 and harvested the fibroblasts at 4 or 12 hours following UV exposure, something unusual happened to the centralized belief paradigm. Their transcript data was analyzed, and found that UV light is the dominant controller of the cell cycle. Imagine that.
They compared the corresponding results in non-irradiated (control) cells. The number of genes with significantly altered expression (≥2-fold difference relative to the control) was higher in the sample irradiated with the highest dose of UV radiation, suggesting that gene expression was utterly UV dose-dependent. The specific pathway analysis was more shocking. It revealed strong, powerful UV light upregulated circadian genes at the 12-hour window, indicating that the expression of MOST of the cell cycle-related genes was predominantly induced by UV light, and it was irrespective of the UV dose used. This hints that UV light is critical to excellent circadian health.
Interestingly, almost all the genes with significantly altered expression were cell cycle-related genes designated as ‘Mitotic Genes’, which function in the spindle assembly checkpoint. Therefore, even a low dose of UV MASSIVELY affects the transcriptional profile of mitosis. This data backs what Gurwitsch found in 1923 in his onion root experiments I mentioned to Huberman earlier this year.